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Pluripotent stem cells exhibiting similar characteristics can be isolated from human fetal bone marrow, heart, liver, muscle, lung, derma, kidney, and fat

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 185-191 doi: 10.1007/s11684-007-0035-1

Abstract: Previously, we reported that a cell population derived from human fetal bone marrow (BM), termed hereIn this study, we further isolated pluripotent stem cells from human fetal heart, liver, muscle, lung, derma, kidney, and fat and then analyzed the characteristics and function of these stem cells.It was found that the phenotype of the culture-expanded pluripotent stem cells from different fetal tissuesIn addition, as fetal BM-derived Flk1CD34 PPSCs, these pluripotent stem cells from different fetal tissues

Keywords： endothelial     phenomenon     ectodermal     Flk1CD34 postembryonic     irradiated non-obese    

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In Vivo Development of Fetal Pig Kidneys in Mature Monkeys Under Clinically Approved Immunosuppressant Article

Tsuyoshi Takamura, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Akimitsu Kobayashi, Izumi Yamamoto, Hiroshi Sasaki, Haruyuki Hirayama, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Akihiko Kiyoshi, Takao Kuroda, Makoto Inoue, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi

Engineering 2022, Volume 10, Issue 3,   Pages 65-73 doi: 10.1016/j.eng.2022.02.001

Abstract: Moreover, to the best of our knowledge, no reports exist on the use of fetal pigs as kidney donors.This study aimed to compare the degree of transplant rejection between neonatal and fetal kidneys, withThe fetal kidneys were transplanted into the omentum and paraaortic regions of cynomolgus monkeys.protocol to the monkeys and the recipient blood vessels flowing into the fetal kidneys.The immunogenicity of fetal kidneys in pig–monkey renal heterotransplantation was lower than that

Keywords： Cynomolgus monkey     Pig     Kidney     Fetal kidney     Immunosuppression    

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Analysis of ultrasonographic diagnosis of fetal malformation

Li Huajie

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 70-72

Abstract: justify;">To investigate the prenatal ultrasound diagnosis (B ultrasound) sonographic characteristics of fetalcongenital malformations，and provide information forclinical，timely termination of pregnancy for fetalmalformation，the production of pregnant womenby ultrasonography，routine obstetric fetal system，measurement，observation of fetal malformation. 42 cases of fetal malformation，2 cases were missed diagnosis.conclusionFetal ultrasonography has important clinical value in diagnosis of malformation.

Keywords： obstetric B ultrasound     fetal malformation     prenatal diagnosis of fetal malformation rate    

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Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 310-318 doi: 10.1007/s11684-017-0542-7

Abstract:

Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD).with normoalbuminuria have progressive renal insufficiency, referred to as normoalbuminuric diabetic kidneyEpidemiologic research has demonstrated that normoalbuminuric diabetic kidney disease is common, and

Keywords： diabetes     diabetic kidney disease     normoalbuminuria     renal impairment    

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Successful kidney transplantation in highly sensitized patients

Weijie ZHANG, Dong CHEN, Zhishui CHEN, Fanjun ZENG, Changsheng MING, Zhengbin LIN, Ping ZHOU, Gang CHEN, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 80-85 doi: 10.1007/s11684-011-0115-0

Abstract: This study reports our experience in kidney transplantation in highly sensitized patients.desensitization using PP/IVIG with or without rituximab increases the likelihood of successful live-donor kidney

Keywords： Kidney transplantation     desensitization    

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Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 389-393 doi: 10.1007/s11684-014-0362-y

Abstract:

Studies conducted by our group on the mechanism of “kidney governing bones” theory in” Although kidney-reinforcing therapy is regarded as one of the holistic regulatory mechanisms” Kidney deficiency refers to a deficiency in only one or more units of the kidney system and notAlthough both classified as kidney-reinforcing agents, the former can resolve failure of the “kidney;kidney governing bones” remains complicated and unresolved.

Keywords： kidney governing bones     kidney deficiency     marrow     osteoporosis     neuroendocrine-immune network     osteoclast    

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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remainHospital from January 1, 2012 to December 31, 2012 according to the AKI diagnosis standard issued by Kidney

Keywords： acute kidney injury     risk factors     prognosis    

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: corresponding tumors is decreased while others remain as valuable as they are in patients with normal kidneyIt has been recently shown that some tumor markers are higher in patients with chronic kidney diseasedecreased while serum AFP, CA, CA, PSA and fPSA were as valuable as they were in patients with normal kidney

Keywords： CKD     non-dialysis     valuable     detection     chronic    

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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 293-304 doi: 10.1007/s11684-019-0715-7

Abstract: This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigatedendogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney

Keywords： netrin-1     VEGF-165     UNC5B     angiogenesis     diabetic kidney disease    

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Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 378-385 doi: 10.1007/s11684-017-0541-8

Abstract: purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney

Keywords： chronic kidney disease     microRNA     mineral bone disorder     uremia    

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Measurement of the normal fetal cardiovascular diameters by echocardiography during the second trimester

Ji Xueqin,Ding Lili,Suo Yaoyu,Shi Ruixian, Liu Yanxiang,Chen Yaoping

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 77-81

Abstract:

To determine the normal range of the inner diameters of the anatomical structures in the fetal cardiovascularThe inner diameters of the fetal atria, ventricles, and great vessels increased with gestational ageIn Ningxia, determining the normal range of fetal cardiovascular diameters during the second trimesterallows the evaluation of fetal cardiovascular system development and provides an important basis forthe accurate identification of fetal congenital heart disease.

Keywords： fetal heart     ultrasound     normal range    

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Leading Approaches to Vascularize Kidney Constructs in Tissue Engineering Review

Diana S. Lim, John D. Jackson, Anthony Atala, James J. Yoo

Engineering 2022, Volume 19, Issue 12,   Pages 117-127 doi: 10.1016/j.eng.2022.05.004

Abstract: Kidney tissue engineering approaches promise to develop alternative solutions that address many of therecellularization approaches, microscale organogenesis, and vascularization using organoids in the context of kidney

Keywords： Kidney     Vascularization     Tissue engineering     Biofabrication     Organoids    

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

Frontiers of Medicine doi: 10.1007/s11684-023-1019-5

Abstract: Studies have found a U-shaped relationship between sleep duration and chronic kidney disease (CKD) risk

Keywords： sleep     physical activity     chronic kidney disease     isotemporal substitution     behavioral pattern    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCC) tissues. We previously showed that ALDOB inhibited proliferation through a mechanism independent of its enzymatic activity in ccRCC, but the mechanism was not unequivocally identified. We showed that the corepressor C-terminal-binding protein 2 (CtBP2) is a novel ALDOB-interacting protein in ccRCC. The CtBP2-to-ALDOB expression ratio in clinical samples was correlated with the expression of CtBP2 target genes and was associated with shorter survival. ALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial marker genes. Furthermore, ALDOB overexpression decreased the proliferation and migration of ccRCC cells in an ALDOB-CtBP2 interaction-dependent manner. Mechanistically, our findings showed that ALDOB recruited acireductone dioxygenase 1, which catalyzes the synthesis of an endogenous inhibitor of CtBP2, 4-methylthio 2-oxobutyric acid. ALDOB functions as a scaffold to bring acireductone dioxygenase and CtBP2 in close proximity to potentiate acireductone dioxygenase-mediated inhibition of CtBP2, and this scaffolding effect was independent of ALDOB enzymatic activity. Moreover, increased ALDOB expression inhibited tumor growth in a xenograft model and decreased lung metastasis in vivo. Our findings reveal that ALDOB is a negative regulator of CtBP2 and inhibits tumor growth and metastasis in ccRCC.

Keywords： ALDOB     kidney cancer     cell proliferation    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRCelevated in the tumor tissues of 83 (63.4%) patients compared with that in their counterpart normal kidney

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Title Author Date Type Operation

Pluripotent stem cells exhibiting similar characteristics can be isolated from human fetal bone marrow, heart, liver, muscle, lung, derma, kidney, and fat

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Journal Article

In Vivo Development of Fetal Pig Kidneys in Mature Monkeys Under Clinically Approved Immunosuppressant

Tsuyoshi Takamura, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Akimitsu Kobayashi, Izumi Yamamoto, Hiroshi Sasaki, Haruyuki Hirayama, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Akihiko Kiyoshi, Takao Kuroda, Makoto Inoue, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi

Journal Article

Analysis of ultrasonographic diagnosis of fetal malformation

Li Huajie

Journal Article

Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Journal Article

Successful kidney transplantation in highly sensitized patients

Weijie ZHANG, Dong CHEN, Zhishui CHEN, Fanjun ZENG, Changsheng MING, Zhengbin LIN, Ping ZHOU, Gang CHEN, Xiaoping CHEN

Journal Article

Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Journal Article

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Journal Article

Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Journal Article

Measurement of the normal fetal cardiovascular diameters by echocardiography during the second trimester

Ji Xueqin,Ding Lili,Suo Yaoyu,Shi Ruixian, Liu Yanxiang,Chen Yaoping

Journal Article

Leading Approaches to Vascularize Kidney Constructs in Tissue Engineering

Diana S. Lim, John D. Jackson, Anthony Atala, James J. Yoo

Journal Article

Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

Journal Article

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples

Journal Article